Protein Details: Neuronal acetylcholine receptor subunit non-alpha-2

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping . Has a role in the determination of life span possibly via calorific restriction which affects growth rate; although this is independent of metabolic activity . Plays a role in the defense against the accumulation of ingested live pathogenic bacteria in the intestine . .

Sequence

PDB Structures

Ligand Binding